9/30/2020 (Week 4)

 

 

Bile salt activated lipase

Cameron Siqueiros

Glendale Community College

 

 

Information from string-database

 

CEL - Bile salt-activated lipase; Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides; Belongs to the type-B carboxylesterase/lipase family

 

LIPE - Hormone-sensitive lipase; In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production; Lipases

 

CTRL - Chymotrypsin-like protease CTRL-1; Chymotrypsin like; Belongs to the peptidase S1 family

 

CPA1 - Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C- terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro; Belongs to the peptidase M14 family

 

PNLIP - Pancreatic lipase; Belongs to the AB hydrolase superfamily. Lipase family

 

PNLIPRP1 - Inactive pancreatic lipase-related protein 1; May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) (By similarity); Belongs to the AB hydrolase superfamily. Lipase family

 

AGK - Acylglycerol kinase, mitochondrial; Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Independently of its lipid kinase activity, acts as a component of the TIM22 complex. The TIM22 complex mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane by forming a twin-pore translocase that uses the membrane potential as the external driving force.

 

MGLL - Monoglyceride lipase; Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth; Lipases

 

LPL - Lipoprotein lipase; The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity); Belongs to the AB hydrolase superfamily. Lipase family

 

DHCR7 - 7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC); Belongs to the ERG4/ERG24 family

 

DHCR24 - Delta(24)-sterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis; Belongs to the FAD-binding oxidoreductase/transferase type 4 family

 

Were the results the same? Were some experimentally validated, and others only predicted?

 

Based off the information from both sites the results were not the same. All of the results from the string-db website were predicted results.

 

Evaluation

From the information I was able to find I concluded that all of the results from the string-db were all predictions of interactions with Bile salt active lipase. I also went back to uniport.org and looked to see if they had any interactions listed under their database as well. The only interaction off of this database was CLC which was not listed in either of the other two databases. I could not find any interactions with other database interactome. Without results from the other database I would have to assume that interactome does not currently have information on interactions with Bile salt activated lipase that have been scientifically experimented and proven.

 

Some images showing the predicted interactions with Bile salt activated lipase




Citations

(n.d.). Retrieved September 28, 2020, from https://string-db.org/cgi/network.pl?taskId=31C1KY7w2PWT

UniProt ConsortiumEuropean Bioinformatics InstituteProtein Information ResourceSIB Swiss Institute of Bioinformatics. (2020, August 12). Bile salt-activated lipase. Retrieved September 28, 2020, from https://www.uniprot.org/uniprot/P19835

HuRI: Home. (n.d.). Retrieved September 28, 2020, from http://www.interactome-atlas.org/

 

Original Links

https://string-db.org/cgi/network.pl?taskId=31C1KY7w2PWT


https://www.uniprot.org/uniprot/P19835

                                                                                   

http://www.interactome-atlas.org/



 

 

 

 

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