S-Stem Scholar Cameron Siqueiros's Blog

    Bile salt activated lipase Cameron Siqueiros Glendale Community College     Information from string-database   CEL - Bile salt-activated lipase; Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides; Belongs to the type-B carboxylesterase/lipase family   LIPE - Hormone-sensitive lipase; In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production; Lipases   CTRL - Chymotrypsin-like protease CTRL-1; Chymotrypsin like; Belongs to the peptidase S1 family   CPA1 - Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C- terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro; Belongs to the peptidase M14 family   PNLIP - Pa...

Cameron Siqueiros   The following screenshots from my results after using I-Tasser 

  Bile salt activated lipase Cameron Siqueiros Glendale Community College   This domain is found repeated at the C-terminus (C-tail) of bile salt-activated lipase, where is O-glycosylated.   Locus – BD014117      3018 bp            DNA     Linear              Pat 27-AUG-2002   Accession number - BD014117   Version – BD014117.1             Comment OS    Homo sapiens (human)             PN    JP 2001112468-A/1             PD    24-APR-2001             PF    08-SEP-2000 JP 2000274215          ...

Cameron Siqueiros     Today I finished my first assignment of the protein bioinformatics project.  I was able to learn about the sequence, function, pathology, and interactions of my assigned protein.  My protein is P19835 Bile Salt activated Lipase (BLSS) . It's function is to catalyze the hydrolysis of different substrates and is an important protein for the digestion of dietary lipids. It is has a chain of 753 amino acids and weighs approximately 79,322 Da. It interacts with Galectin-10 which is an important factor for anergy and suppressive functions of CD25-positive regulatory T-cells. BLSS is also involved with maturity onset diabetes of the young 8 with exocrine dysfunction (MODY8). It is caused by a mutation in the CEL gene. I am looking forward to learning more about my protein.