S-Stem Scholar Cameron Siqueiros's Blog

    Bile salt activated lipase Cameron Siqueiros Glendale Community College   Name – Bile salt-activated lipase   ID Number – P19835   Uniprot ID – Q16398   Diseases – Bile salt-activated lipase is associated with MODY8 (maturity onset diabetes of the young 8 with exocrine dysfunction   Catalytic activity – Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+) Reaction=1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)- octadecenoate + di-(9Z)-octadecenoylglycerol + H(+) Reaction=1,2,3-trioctanoylglycerol + H2O = dioctanoylglycerol + H(+) + octanoate Reaction=a sterol ester + H2O = a fatty acid + a sterol + H(+) Reaction=cholesteryl (9Z-octadecenoate) + H2O = (9Z)-octadecenoate + cholesterol + H(+) Reaction=an acetyl ester + H2O = acetate + an aliphatic alcohol + H(+) Reaction=butanoate ester + H2O = an aliphatic alcohol + butanoate + H(+) Reaction=9-hexadecanoyloxy-octadecanoate + H2O = 9-hydroxy- oc...

  Bile salt activated lipase Cameron Siqueiros Glendale Community College   Protein – P19835 (Bile salt-activated lipase)   Description - Bile salt-activated lipase is a major triglyceride, cholesterol ester and vitamin ester hydrolytic enzyme contained within pancreatic and lactating mammary gland secretions. It requires bile salts for activation. The biological process of bile salt activated lipase is known as lipid metabolic process.   Molecular function – hydrolase activity acting on ester bonds.   Function – to catalyze the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysopholipids, di-acylglycerols, tri-acylglycerols, and fatty acid esters of hydroxy fatty acids or (FAHFAS). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed quicker than saturated FAHFA. Plays an important role in complete digestion of dietary lipids and their...